|Application ||WB, E|
|Other Accession||P32736, P11834, NP_002536.1|
|Calculated MW||38008 Da|
|Antigen Region||172-200 aa|
|Other Names||Opioid-binding protein/cell adhesion molecule, OBCAM, OPCML, Opioid-binding cell adhesion molecule, IgLON family member 1, OPCML, IGLON1, OBCAM|
|Target/Specificity||This OPCML antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the Central region of human OPCML.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OPCML Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds opioids in the presence of acidic lipids; probably involved in cell contact.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene.
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Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Stolk, L., et al. Nat. Genet. (2009) In press :
Cui, Y., et al. PLoS ONE 3 (8), E2990 (2008) :
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