PIH1D1 Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9NWS0 |
Other Accession | NP_060386.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 32363 Da |
Antigen Region | 163-192 aa |
Gene ID | 55011 |
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Other Names | PIH1 domain-containing protein 1, Nucleolar protein 17 homolog, PIH1D1, NOP17 |
Target/Specificity | This PIH1D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-192 amino acids from the Central region of human PIH1D1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PIH1D1 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PIH1D1 |
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Synonyms | NOP17 |
Function | Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9CQJ2}. |
Tissue Location | Expressed at low levels in normal mammary epithelial cells (at protein level) (PubMed:24036451). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen, testis and thymus (PubMed:21078300) |
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Provided below are standard protocols that you may find useful for product applications.
Background
PIH1D1 belongs to the PIH1 family.
References
Cloutier, P., et al. Methods 48(4):381-386(2009)
McKeegan, K.S., et al. Mol. Cell. Biol. 27(19):6782-6793(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Gonzales, F.A., et al. J. Mol. Biol. 346(2):437-455(2005)
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