|Application ||WB, E|
|Calculated MW||32363 Da|
|Antigen Region||163-192 aa|
|Other Names||PIH1 domain-containing protein 1, Nucleolar protein 17 homolog, PIH1D1, NOP17|
|Target/Specificity||This PIH1D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-192 amino acids from the Central region of human PIH1D1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIH1D1 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451).|
|Tissue Location||Expressed at low levels in normal mammary epithelial cells (at protein level) (PubMed:24036451). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen, testis and thymus (PubMed:21078300).|
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Provided below are standard protocols that you may find useful for product applications.
PIH1D1 belongs to the PIH1 family.
Cloutier, P., et al. Methods 48(4):381-386(2009)
McKeegan, K.S., et al. Mol. Cell. Biol. 27(19):6782-6793(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Gonzales, F.A., et al. J. Mol. Biol. 346(2):437-455(2005)
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