|Application ||WB, E|
|Calculated MW||32363 Da|
|Antigen Region||163-192 aa|
|Other Names||PIH1 domain-containing protein 1, Nucleolar protein 17 homolog, PIH1D1, NOP17|
|Target/Specificity||This PIH1D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-192 amino acids from the Central region of human PIH1D1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIH1D1 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451).|
|Tissue Location||Expressed at low levels in normal mammary epithelial cells (at protein level) (PubMed:24036451). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen, testis and thymus (PubMed:21078300).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
PIH1D1 belongs to the PIH1 family.
Cloutier, P., et al. Methods 48(4):381-386(2009)
McKeegan, K.S., et al. Mol. Cell. Biol. 27(19):6782-6793(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Gonzales, F.A., et al. J. Mol. Biol. 346(2):437-455(2005)
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