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Rat Ggt1 Antibody(N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P07314 |
| Other Accession | NP_446292.2 |
| Reactivity | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 61610 Da |
| Antigen Region | 12-39 aa |
| Gene ID | 116568 |
|---|---|
| Other Names | Gamma-glutamyltranspeptidase 1, GGT 1, Gamma-glutamyltransferase 1, Glutathione hydrolase 1, Leukotriene-C4 hydrolase, CD224, Gamma-glutamyltranspeptidase 1 heavy chain, Gamma-glutamyltranspeptidase 1 light chain, Ggt1, Ggt |
| Target/Specificity | This Rat Ggt1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of rat Ggt1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Rat Ggt1 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ggt1 |
|---|---|
| Synonyms | Ggt |
| Function | Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates (such as maresin conjugate (13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)- docosahexaenoate, MCTR1) and other gamma-glutamyl compounds (such as leukotriene C4, LTC4) (PubMed:6122208) (By similarity). The metabolism of glutathione by GGT1 releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases (PubMed:6122208). In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:6122208). Contributes to cysteine homeostasis, glutathione homeostasis and in the conversion of the leukotriene LTC4 to LTD4 (PubMed:6122208). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P19440}; Single-pass type II membrane protein |
| Tissue Location | Detected in adult kidney and mammary gland, and in fetal liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate.
References
Aly, H.A., et al. Chem. Biol. Interact. 182 (2-3), 112-118 (2009) :
Zheng, M.Q., et al. Am. J. Physiol., Cell Physiol. 297 (2), C253-C262 (2009) :
Hamden, K., et al. Steroids 73(5):495-501(2008)
Pandur, S., et al. Free Radic. Res. 41(12):1376-1384(2007)
Hamden, K., et al. J. Physiol. Biochem. 63(3):195-201(2007)
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