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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Shc4 Antibody(C-term)   

Mouse Shc4 Antibody(C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Shc4 Antibody(C-term) AP19647b
    Mouse Shc4 Antibody (C-term) (Cat. #AP19647b) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Mouse Shc4 antibody detected the Mouse Shc4 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6S5L9
Other Accession NP_950187.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68519 Da
Antigen Region 590-617 aa
Additional Information
Gene ID 271849
Other Names SHC-transforming protein 4, Rai-like protein, RaLP, SHC-transforming protein D, mShcD, Src homology 2 domain-containing-transforming protein C4, SH2 domain protein C4, Shc4, Shcd
Target/Specificity This Mouse Shc4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 590-617 amino acids from the C-terminal region of mouse Shc4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Shc4 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Shc4
Synonyms Shcd
Function Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Cellular Location Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction
Tissue Location Expressed in both brain and skeletal muscle; widely expressed in brain namely olfactory bulb, cortex, hippocampus, striatum, thalamus, and brain stem (at protein level). Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.
Research Areas
Citations (0)

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Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.


Jones, N., et al. Mol. Cell. Biol. 27(13):4759-4773(2007)
Fagiani, E., et al. Cancer Res. 67(7):3064-3073(2007)

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$ 295.00
$ 99.00
Cat# AP19647b
(40 western blots)
Availability: In Stock
Bulk Size
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