|Application ||WB, E|
|Calculated MW||68519 Da|
|Antigen Region||590-617 aa|
|Other Names||SHC-transforming protein 4, Rai-like protein, RaLP, SHC-transforming protein D, mShcD, Src homology 2 domain-containing-transforming protein C4, SH2 domain protein C4, Shc4, Shcd|
|Target/Specificity||This Mouse Shc4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 590-617 amino acids from the C-terminal region of mouse Shc4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||Mouse Shc4 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction|
|Tissue Location||Expressed in both brain and skeletal muscle; widely expressed in brain namely olfactory bulb, cortex, hippocampus, striatum, thalamus, and brain stem (at protein level). Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential.|
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Provided below are standard protocols that you may find useful for product applications.
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.
Jones, N., et al. Mol. Cell. Biol. 27(13):4759-4773(2007)
Fagiani, E., et al. Cancer Res. 67(7):3064-3073(2007)
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