|Application ||WB, E|
|Calculated MW||45674 Da|
|Antigen Region||1-30 aa|
|Other Names||Dipeptidase 1, Dehydropeptidase-I, Microsomal dipeptidase, Renal dipeptidase, hRDP, DPEP1, MDP, RDP|
|Target/Specificity||This DPEP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DPEP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DPEP1 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.|
|Cellular Location||Apical cell membrane; Lipid-anchor, GPI- anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI- anchor. Note=Brush border membrane|
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Provided below are standard protocols that you may find useful for product applications.
DPEP1 (EC 18.104.22.168) is a kidney membrane enzyme that hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates, e.g., leukotriene D4 (Kozak and Tate, 1982 [PubMed 6122685]). DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics, such as penem and carbapenem (Campbell et al., 1984 [PubMed 6334084]). Earlier, beta-lactamase enzymes were thought to occur only in bacteria, where their probable function was in protecting the organisms against the action of beta-lactam antibiotics. These antibiotics exhibit selective toxicity against bacteria but virtual inertness against many eukaryotic cells (Adachi et al., 1990 [PubMed 2303490]).
Nan, H., et al. J. Invest. Dermatol. 129(9):2250-2257(2009)
Pare, G., et al. Circ Cardiovasc Genet 2(2):142-150(2009)
Nitanai, Y., et al. J. Mol. Biol. 321(2):177-184(2002)
Kera, Y., et al. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 123(1):53-58(1999)
Satoh, S., et al. Biotechnol. Prog. 10(2):134-140(1994)
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