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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   BRAP Antibody(N-term)   

BRAP Antibody(N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BRAP Antibody(N-term) AP19664a
    BRAP Antibody (N-term) (Cat. #AP19664a) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the BRAP antibody detected the BRAP protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z569
Other Accession NP_006759.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 67305 Da
Antigen Region 66-95 aa
Additional Information
Gene ID 8315
Other Names BRCA1-associated protein, 632-, BRAP2, Impedes mitogenic signal propagation, IMP, RING finger protein 52, Renal carcinoma antigen NY-REN-63, BRAP (HGNC:1099), RNF52
Target/Specificity This BRAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-95 amino acids from the N-terminal region of human BRAP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBRAP Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BRAP (HGNC:1099)
Synonyms RNF52
Function Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Cellular Location Cytoplasm.
Tissue Location Expressed in breast epithelial cell lines.
Research Areas
Citations (0)

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The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm.


Fulcher, A.J., et al. FASEB J. 24(5):1454-1466(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
Hinohara, K., et al. J. Hum. Genet. 54(11):642-646(2009)
Cui, R., et al. Gastroenterology 137(5):1768-1775(2009)

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$ 295.00
$ 99.00
Cat# AP19664a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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