|Application ||WB, E|
|Other Accession||NP_001035972.1, NP_002298.1|
|Calculated MW||15075 Da|
|Antigen Region||54-82 aa|
|Other Names||Galectin-7, Gal-7, HKL-14, PI7, p53-induced gene 1 protein, LGALS7, PIG1|
|Target/Specificity||This LGALS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the Central region of human LGALS7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LGALS7 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.|
|Cellular Location||Cytoplasm. Nucleus. Secreted Note=May be secreted by a non-classical secretory pathway|
|Tissue Location||Mainly expressed in stratified squamous epithelium|
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Provided below are standard protocols that you may find useful for product applications.
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:653499) is found adjacent to, but on the opposite strand on chromosome 19.
Demers, M., et al. Am. J. Pathol. 176(6):3023-3031(2010)
Zhu, X., et al. BMC Cancer 10, 290 (2010) :
Park, J.E., et al. Oncol. Rep. 22(6):1373-1379(2009)
Demers, M., et al. Biochem. Biophys. Res. Commun. 387(3):425-429(2009)
Saussez, S., et al. Int. J. Oncol. 34(2):433-439(2009)
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