|Application ||WB, E|
|Other Accession||Q9Z331, NP_032502.3|
|Calculated MW||59335 Da|
|Antigen Region||212-240 aa|
|Other Names||Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Keratin-6-alpha, mK6-alpha, Keratin-6A, K6A, Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6|
|Target/Specificity||This Mouse Krt6a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of mouse Krt6a.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Krt6a Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||Ker2, Krt2-6, Krt2-6a, Krt6|
|Function||Epidermis-specific type I keratin involved in wound healing (PubMed:10866680). Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration (PubMed:10866680). Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair (PubMed:22529101).|
|Tissue Location||Predominates in the adult trunk skin, tongue, trachea/esophagus and eye. In adult skin, localization is restricted to hair follicles, where it is localized predominantly in the outer root sheath.|
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Provided below are standard protocols that you may find useful for product applications.
Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation related keratins). Keratin 6 is found in hair follicles, neck squamous cell carcinomas, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation. There are at least six isoforms of human type II keratin 6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.
Sehic, A., et al. Eur. J. Oral Sci. 117(2):93-104(2009)
Chen, J., et al. J. Invest. Dermatol. 128(2):270-279(2008)
Cui, C.Y., et al. Hum. Mol. Genet. 16(21):2583-2590(2007)
Gu, L.H., et al. J. Invest. Dermatol. 127(5):1061-1073(2007)
Kurek, D., et al. Development 134(2):261-272(2007)
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