|Application ||WB, E|
|Calculated MW||72511 Da|
|Antigen Region||262-289 aa|
|Other Names||Sentrin-specific protease 1, SUMO-1 protease 2, SuPr-2, Sentrin/SUMO-specific protease SENP1, Senp1, Supr2|
|Target/Specificity||This Mouse Senp1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-289 amino acids from the Central region of mouse Senp1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Senp1 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1.|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus|
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Provided below are standard protocols that you may find useful for product applications.
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.
Bawa-Khalfe, T., et al. J. Biol. Chem. 285(33):25859-25866(2010)
Yu, L., et al. J. Exp. Med. 207(6):1183-1195(2010)
Sharma, P., et al. J. Cell. Sci. 123 (PT 8), 1227-1234 (2010) :
Li, X., et al. Cell Death Differ. 15(4):739-750(2008)
Cheng, J., et al. Cell 131(3):584-595(2007)
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