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SETD3 Antibody(C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SETD3 Antibody(C-term) AP19739B
    SETD3 Antibody (C-term) (Cat. #AP19739b) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SETD3 antibody detected the SETD3 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q86TU7
Other Accession NP_115609.2, NP_954574.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 67257 Da
Antigen Region 556-585 aa
Additional Information
Gene ID 84193
Other Names Histone-lysine N-methyltransferase setd3, SET domain-containing protein 3, SETD3, C14orf154
Target/Specificity This SETD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 556-585 amino acids from the C-terminal region of human SETD3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSETD3 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SETD3
Function Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847, PubMed:30626964, PubMed:30785395, PubMed:31388018, PubMed:31993215). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N- methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964, PubMed:30785395, PubMed:31388018).
Cellular Location Cytoplasm. Nucleus Note=Localizes mainly in the cytoplasm.
Research Areas
Citations (0)
citation

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Background

SETD3 contains 1 SET domain. The function of the SETD3 protein remains unknown. There are 3 isoforms produced by alternative splicing.

References

Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)
Tao, W.A., et al. Nat. Methods 2(8):591-598(2005)
Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)

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$ 365.00
$ 140.00
Cat# AP19739B
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