|Application ||WB, E|
|Calculated MW||60513 Da|
|Antigen Region||68-96 aa|
|Other Names||UDP-glucuronosyltransferase 2B4, UDPGT 2B4, HLUG25, Hyodeoxycholic acid-specific UDPGT, UDPGTh-1, UGT2B4, UGT2B11|
|Target/Specificity||This UGT2B4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-96 amino acids from the N-terminal region of human UGT2B4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UGT2B4 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.|
|Cellular Location||Microsome membrane; Single- pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Levesque, E., et al. Pharmacogenet. Genomics 20(3):195-210(2010)
Yong, M., et al. Cancer Epidemiol. Biomarkers Prev. 19(2):537-546(2010)
Li, J., et al. Breast Cancer Res. 12 (2), R19 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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