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NXT1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NXT1 Antibody (C-term) AP19752b
    NXT1 Antibody (C-term) (Cat. #AP19752b) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the NXT1 antibody detected the NXT1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UKK6
Other Accession Q9QZV9, Q2KIW0, NP_037380.1
Reactivity Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 85-111 aa
Additional Information
Other Names NTF2-related export protein 1, Protein p15, NXT1
Target/Specificity This NXT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-111 amino acids from the C-terminal region of human NXT1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNXT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NXT1
Function Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602).
Cellular Location Nucleus. Nucleus speckle. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm EMBL; AF156957; AAD54942.1; -; mRNA EMBL; AL096677; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; BC000759; AAH00759.1; -; mRNA EMBL; BC002687; AAH02687.1; -; mRNA EMBL; BC003029; AAH03029.1; -; mRNA EMBL; BC003410; AAH03410.1; -; mRNA CCDS; CCDS13150.1; - RefSeq; NP_037380.1; NM_013248.2 RefSeq; XP_011527532.1; XM_011529230.2 UniGene; Hs.516933; - PDB; 1JKG; X-ray; 1.90 A; A=1-140 PDB; 1JN5; X-ray; 2.80 A; A=1-140 PDB; 4WYK; X-ray; 3.40 A; B/D=2-140 PDBsum; 1JKG; - PDBsum; 1JN5; - PDBsum; 4WYK; - ProteinModelPortal; Q9UKK6; - SMR; Q9UKK6; - BioGrid; 118875; 12 DIP; DIP-33075N; - IntAct; Q9UKK6; 16 MINT; Q9UKK6; - STRING; 9606.ENSP00000254998; - iPTMnet; Q9UKK6; - PhosphoSitePlus; Q9UKK6; - BioMuta; NXT1; - DMDM; 18203504; - EPD; Q9UKK6; - MaxQB; Q9UKK6; - PaxDb; Q9UKK6; - PeptideAtlas; Q9UKK6; - PRIDE; Q9UKK6; - ProteomicsDB; 84812; - TopDownProteomics; Q9UKK6; - Ensembl; ENST00000254998; ENSP00000254998; ENSG00000132661 GeneID; 29107; - KEGG; hsa:29107; - UCSC; uc002wsx.2; human CTD; 29107; - DisGeNET; 29107; - EuPathDB; HostDB:ENSG00000132661.3; - GeneCards; NXT1; - HGNC; HGNC:15913; NXT1 HPA; HPA047471; - MIM; 605811; gene neXtProt; NX_Q9UKK6; - OpenTargets; ENSG00000132661; - PharmGKB; PA31867; - eggNOG; KOG4353; Eukaryota eggNOG; ENOG4111TWR; LUCA GeneTree; ENSGT00510000046494; - HOGENOM; HOG000231890; - HOVERGEN; HBG018207; - InParanoid; Q9UKK6; - KO; K14285; - OMA; YYSTMDK; - OrthoDB; EOG091G0SMX; - PhylomeDB; Q9UKK6; - TreeFam; TF318944; - Reactome; R-HSA-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript ChiTaRS; NXT1; human EvolutionaryTrace; Q9UKK6; - GeneWiki; NXT1; - GenomeRNAi; 29107; - PRO; PR:Q9UKK6; - Proteomes; UP000005640; Chromosome 20 Bgee; ENSG00000132661; - CleanEx; HS_NXT1; - Genevisible; Q9UKK6; HS GO; GO:0005737; C:cytoplasm; TAS:ProtInc GO; GO:0005829; C:cytosol; IDA:HPA GO; GO:0005643; C:nuclear pore; TAS:ProtInc GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:0008536; F:Ran GTPase binding; IEA:Ensembl GO; GO:0006406; P:mRNA export from nucleus; TAS:Reactome CDD; cd00780; NTF2; 1 InterPro; IPR002075; NTF2 InterPro; IPR032710; NTF2-like_dom_sf InterPro; IPR018222; Nuclear_transport_factor_2_euk Pfam; PF02136; NTF2; 1 SUPFAM; SSF54427; SSF54427; 1 PROSITE; PS50177; NTF2_DOMAIN; 1 1: Evidence at protein level; 3D-structure; Acetylation; Complete proteome; Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport INIT_MET 1 1 Removed. CHAIN 2 140 NTF2-related export protein 1 /FTId=PRO_0000194793 DOMAIN 16 135 NTF2. {ECO:0000255|PROSITE- ProRule:PRU00137} MOD_RES 2 2 N-acetylalanine MUTAGEN 114 114 I->R: 70% reduction in mRNA export activity. MUTAGEN 134 134 R->D: 57% reduction in mRNA export activity and loss of nuclear rim staining. HELIX 6 30 {ECO:0000244|PDB:1JKG} HELIX 32 38 {ECO:0000244|PDB:1JKG} STRAND 39 47 {ECO:0000244|PDB:1JKG} STRAND 50 54 {ECO:0000244|PDB:1JKG} HELIX 55 64 {ECO:0000244|PDB:1JKG} STRAND 68 79 {ECO:0000244|PDB:1JKG} TURN 82 84 {ECO:0000244|PDB:1JKG} STRAND 90 101 {ECO:0000244|PDB:1JKG} STRAND 107 118 {ECO:0000244|PDB:1JKG} STRAND 121 123 {ECO:0000244|PDB:1JKG} STRAND 125 135 {ECO:0000244|PDB:1JKG} TURN 136 139 {ECO:0000244|PDB:1JKG} SEQUENCE 140 AA; 15847 MW; 358FA86AC3944594 CRC64; MASVDFKTYV DQACRAAEEF VNVYYTTMDK RRRLLSRLYM GTATLVWNGN AVSGQESLSE FFEMLPSSEF QISVVDCQPV HDEATPSQTT VLVVICGSVK FEGNKQRDFN QNFILTAQAS PSNTVWKIAS DCFRFQDWAS
Research Areas
Citations (0)

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Background

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.

References

Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Forler, D., et al. Nat. Biotechnol. 21(1):89-92(2003)
Katahira, J., et al. J. Biol. Chem. 277(11):9242-9246(2002)
Wiegand, H.L., et al. Mol. Cell. Biol. 22(1):245-256(2002)
Deloukas, P., et al. Nature 414(6866):865-871(2001)

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$ 295.00
$ 99.00
Cat# AP19752b
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(40 western blots)
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