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PRRX2 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PRRX2 Antibody (C-term) AP19763b
    PRRX2 Antibody (C-term) (Cat. #AP19763b) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the PRRX2 antibody detected the PRRX2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q99811
Other Accession Q06348, NP_057391.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 27079 Da
Antigen Region 223-250 aa
Additional Information
Gene ID 51450
Other Names Paired mesoderm homeobox protein 2, Paired-related homeobox protein 2, PRX-2, PRRX2, PMX2, PRX2
Target/Specificity This PRRX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-250 amino acids from the C-terminal region of human PRRX2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPRRX2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRRX2
Synonyms PMX2, PRX2
Function May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}
Tissue Location In fetal skin, highest expression found in cells of mesodermal origin within the dermal papilla of the developing hair shaft. Not detected in epidermis or dermis. In adult skin, weakly expressed within the basal layers of the epidermis. Not expressed in dermis.
Citations (0)
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Background

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation.

References

Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Eriksson, N., et al. PLoS Genet. 6 (6), E1000993 (2010) :
Tokutomi, Y., et al. Biochem. Biophys. Res. Commun. 364(4):822-830(2007)
Wissmuller, S., et al. Nucleic Acids Res. 34(6):1735-1744(2006)
Gervais, C., et al. Leukemia 19(1):145-148(2005)

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$ 365.00
$ 140.00
Cat# AP19763b
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