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>   home   >   Products   >   Primary Antibodies   >   TFAP2A Antibody (C-term)   

TFAP2A Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TFAP2A Antibody (C-term) AP1976b
    Western blot analysis of TFAP2A Antibody (C-term) (Cat# AP1976b) in NCI-H460 cell line lysates (35ug/lane). TFAP2A (arrow) was detected using the purified Pab.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P05549
Other Accession A1A4R9
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 48062 Da
Antigen Region 407-436 aa
Additional Information
Gene ID 7020
Other Names Transcription factor AP-2-alpha, AP2-alpha, AP-2 transcription factor, Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2, TFAP2A, AP2TF, TFAP2
Target/Specificity This TFAP2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-436 amino acids from the C-terminal region of human TFAP2A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTFAP2A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TFAP2A
Synonyms AP2TF, TFAP2
Function Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
Cellular Location Nucleus.
Citations (0)

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Background

TFAP2A is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2A is the only AP-2 protein required for early morphogenesis of the lens vesicle.

References

Provenzano,M.J., Exp. Mol. Pathol. 83 (2), 277-282 (2007)
Tan,Y.R., Biochem. J. 405 (1), 131-137 (2007)
Liu,H., EMBO Rep. 8 (4), 394-400 (2007)
Han,S., J. Biol. Chem. 282 (11), 7961-7972 (2007)

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$ 295.00
$ 99.00
Cat# AP1976b
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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