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LIN7B Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - LIN7B Antibody (N-term) AP19782a
    LIN7B Antibody (N-term) (Cat. #AP19782a) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the LIN7B antibody detected the LIN7B protein (arrow).
    detail
  • WB - LIN7B Antibody (N-term) AP19782a
    LIN7B Antibody (N-term) (Cat. #AP19782a) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the LIN7B antibody detected the LIN7B protein (arrow).
    detail
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9HAP6
Other Accession Q9Z252, O88951, Q2KIB6, NP_071448.1
Reactivity Human, Mouse
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 22896 Da
Antigen Region 35-62 aa
Additional Information
Gene ID 64130
Other Names Protein lin-7 homolog B, Lin-7B, hLin7B, Mammalian lin-seven protein 2, MALS-2, Vertebrate lin-7 homolog 2, Veli-2, hVeli2, LIN7B, MALS2, VELI2
Target/Specificity This LIN7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human LIN7B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLIN7B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LIN7B
Synonyms MALS2, VELI2
Function Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta- catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:O88951}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Basolateral cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Cell junction {ECO:0000250|UniProtKB:O88951}. Postsynaptic density membrane {ECO:0000250|UniProtKB:O88951}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Cell junction, tight junction {ECO:0000250|UniProtKB:O88951}. Note=Mainly basolateral in renal epithelial cells.
Research Areas
Citations (0)
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Background

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).

References

Zucker, B., et al. J. Neuropathol. Exp. Neurol. 69(9):880-895(2010)
Lanktree, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (6), 945-951 (2008) :
Sudo, K., et al. Neurosci. Res. 56(4):347-355(2006)
Li, Z., et al. J. Biol. Chem. 281(16):11066-11073(2006)
Kawai, S., et al. J. Biol. Chem. 280(47):39200-39207(2005)

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$ 182.50
$ 70.00
Cat# AP19782a
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