|Application ||WB, E|
|Calculated MW||80105 Da|
|Antigen Region||187-214 aa|
|Other Names||Rho guanine nucleotide exchange factor 16, Ephexin-4, ARHGEF16, EPHEXIN4, NBR|
|Target/Specificity||This ARHGEF16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 187-214 amino acids from the N-terminal region of human ARHGEF16.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARHGEF16 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.|
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Provided below are standard protocols that you may find useful for product applications.
Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions.
Hiramoto-Yamaki, N., et al. J. Cell Biol. 190(3):461-477(2010)
Takefuji, M., et al. J. Hum. Genet. 55(1):42-49(2010)
Barber, M.J., et al. PLoS ONE 5 (3), E9763 (2010) :
Rabizadeh, S., et al. Cytokine Growth Factor Rev. 14 (3-4), 225-239 (2003) :
Salehi, A.H., et al. J. Biol. Chem. 277(50):48043-48050(2002)
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