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PLD3 Antibody(N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8IV08 |
| Other Accession | Q5FVH2, O35405, Q4R583, Q2KJJ8, NP_036400.2 |
| Reactivity | Mouse |
| Predicted | Bovine, Monkey, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54705 Da |
| Antigen Region | 9-37 aa |
| Gene ID | 23646 |
|---|---|
| Other Names | Phospholipase D3, PLD 3, Choline phosphatase 3, HindIII K4L homolog, Hu-K4, Phosphatidylcholine-hydrolyzing phospholipase D3, PLD3 |
| Target/Specificity | This PLD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human PLD3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PLD3 Antibody(N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PLD3 |
|---|---|
| Function | 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (PubMed:30312375). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation (PubMed:22428023). Plays a role in lysosomal homeostasis (PubMed:28128235). Involved in the regulation of endosomal protein sorting (PubMed:29368044). |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein. Lysosome lumen. Early endosome membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Golgi apparatus membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein. Note=Localizes to ER-associated vesicles in differentiating myotubes (PubMed:22428023). The soluble form in lysosome arises by proteolytic processing of the membrane-bound form (PubMed:29386126). Colocalizes with APP in endosomes (PubMed:29368044) |
| Tissue Location | Widely expressed. In the brain, high levels of expression are detected in the frontal, temporal and occipital cortices and hippocampus. Expressed at low level in corpus callosum |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein is unknown.
References
Idkowiak-Baldys, J., et al. J. Biol. Chem. 284(33):22322-22331(2009)
Walker, L.C., et al. Breast Cancer Res. Treat. 112(2):229-236(2008)
Russo, P., et al. Am. J. Hypertens. 19(4):331-338(2006)
Cheng, J., et al. Science 308(5725):1149-1154(2005)
Munck, A., et al. FEBS J. 272(7):1718-1726(2005)
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