|Application ||WB, E|
|Other Accession||Q91YI1, NP_001136145.1|
|Calculated MW||56572 Da|
|Antigen Region||333-362 aa|
|Other Names||Autophagy-related protein 13, ATG13, KIAA0652|
|Target/Specificity||This ATG13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-362 amino acids from the Central region of human ATG13.|
|Precautions||ATG13 Antibody (Center S355.) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|
|Cellular Location||Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation|
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Provided below are standard protocols that you may find useful for product applications.
Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.
Ferreira, R.C., et al. Nat. Genet. 42(9):777-780(2010)
Hosokawa, N., et al. Autophagy 5(7):973-979(2009)
Mercer, C.A., et al. Autophagy 5(5):649-662(2009)
Ganley, I.G., et al. J. Biol. Chem. 284(18):12297-12305(2009)
Chan, E.Y., et al. Mol. Cell. Biol. 29(1):157-171(2009)
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