|Application ||WB, E|
|Other Accession||Q4R947, NP_006704.3|
|Calculated MW||14395 Da|
|Antigen Region||18-47 aa|
|Other Names||Activated RNA polymerase II transcriptional coactivator p15, Positive cofactor 4, PC4, SUB1 homolog, p14, SUB1, PC4, RPO2TC1|
|Target/Specificity||This SUB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the Central region of human SUB1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SUB1 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|
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General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
Das, C., et al. J. Mol. Biol. 397(1):1-12(2010)
Rajagopalan, S., et al. J. Biol. Chem. 284(32):21728-21737(2009)
Mortusewicz, O., et al. J. Cell Biol. 183(5):769-776(2008)
Batta, K., et al. Mol. Cell. Biol. 27(21):7603-7614(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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