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SUB1 Antibody(Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P53999 |
| Other Accession | Q4R947, NP_006704.3 |
| Reactivity | Human |
| Predicted | Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 14395 Da |
| Antigen Region | 18-47 aa |
| Gene ID | 10923 |
|---|---|
| Other Names | Activated RNA polymerase II transcriptional coactivator p15, Positive cofactor 4, PC4, SUB1 homolog, p14, SUB1, PC4, RPO2TC1 |
| Target/Specificity | This SUB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the Central region of human SUB1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SUB1 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SUB1 |
|---|---|
| Synonyms | PC4, RPO2TC1 |
| Function | General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
References
Das, C., et al. J. Mol. Biol. 397(1):1-12(2010)
Rajagopalan, S., et al. J. Biol. Chem. 284(32):21728-21737(2009)
Mortusewicz, O., et al. J. Cell Biol. 183(5):769-776(2008)
Batta, K., et al. Mol. Cell. Biol. 27(21):7603-7614(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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