|Application ||WB, IHC-P, E|
|Calculated MW||76877 Da|
|Antigen Region||154-183 aa|
|Other Names||Zinc finger protein 219, ZNF219|
|Target/Specificity||This ZNF219 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the N-terminal region of human ZNF219.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNF219 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
ZNF219 is a member of the Kruppel-like zinc finger family that is involved in a diverse range of biological processes. ZNF219 is a 77-kDa nuclear protein containing nine sets of C2H2 zinc finger structures. It may be involved in transcriptional regulation, it functions as a transcriptional repressor for the HMGN1 promoter
Olsen,J.V., Cell 127 (3), 635-648 (2006)
Paces-Fessy,M., Biochem. J. 378 (PT 2), 353-362 (2004)
Sakai,T., DNA Res. 10 (4), 155-165 (2003)
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