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ZNF219 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9P2Y4 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 76877 Da |
| Antigen Region | 653-682 aa |
| Gene ID | 51222 |
|---|---|
| Other Names | Zinc finger protein 219, ZNF219 |
| Target/Specificity | This ZNF219 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 653-682 amino acids from the C-terminal region of human ZNF219. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZNF219 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZNF219 |
|---|---|
| Function | Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG- 3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). |
| Cellular Location | Nucleus |
| Tissue Location | Ubiquitous.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ZNF219 is a member of the Kruppel-like zinc finger gene family that is involved in a diverse range of biological processes. ZNF219 is a 77-kDa nuclear protein containing nine sets of C2H2 zinc finger structures. It may be involved in transcriptional regulation, it functioned as a transcriptional repressor for the HMGN1 promoter
References
Olsen,J.V., Cell 127 (3), 635-648 (2006)
Paces-Fessy,M., Biochem. J. 378 (PT 2), 353-362 (2004)
Sakai,T., DNA Res. 10 (4), 155-165 (2003)
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