|Application ||WB, E|
|Other Accession||Q15415, A6NEQ0, P0C7P1, P0DJD4, A6NDE4, Q15414, NP_005049.1|
|Calculated MW||55784 Da|
|Antigen Region||468-496 aa|
|Other Names||RNA-binding motif protein, Y chromosome, family 1 member A1, RNA-binding motif protein 1, RNA-binding motif protein 2, Y chromosome RNA recognition motif 1, hRBMY, RBMY1A1, RBM1, RBM2, YRRM1, YRRM2|
|Target/Specificity||This RBMY1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 468-496 amino acids from the C-terminal region of human RBMY1A1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RBMY1A1 Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||RBM1, RBM2, YRRM1, YRRM2|
|Function||RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. [provided by RefSeq].
Dreumont, N., et al. J. Cell. Sci. 123 (PT 1), 40-50 (2010) :
Liu, Y., et al. PLoS Genet. 5 (11), E1000707 (2009) :
Lardone, M.C., et al. Mol. Hum. Reprod. 13(10):705-712(2007)
Skrisovska, L., et al. EMBO Rep. 8(4):372-379(2007)
Lavery, R., et al. Arch. Androl. 53(2):71-73(2007)
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