|Application ||WB, E|
|Other Accession||Q8WN97, O77649, O97951, O75795, P54855, O75310, P36537, O02663, P16662, P06133, NP_444267.1|
|Calculated MW||60906 Da|
|Antigen Region||218-246 aa|
|Other Names||UDP-glucuronosyltransferase 2B28, UDPGT 2B28, UGT2B28|
|Target/Specificity||This UGT2B28 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-246 amino acids from the Central region of human UGT2B28.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UGT2B28 Antibody(Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta- diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.|
|Cellular Location||Microsome membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein|
|Tissue Location||Expressed in the liver, breast and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.
Setlur, S.R., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):229-239(2010)
Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)
Menard, V., et al. Hum. Mutat. 30(9):1310-1319(2009)
Levesque, E., et al. Biochemistry 40(13):3869-3881(2001)
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