|Application ||WB, E|
|Calculated MW||41955 Da|
|Antigen Region||1-30 aa|
|Other Names||C-X-C chemokine receptor type 5, CXC-R5, CXCR-5, Burkitt lymphoma receptor 1, Monocyte-derived receptor 15, MDR-15, CD185, CXCR5, BLR1, MDR15|
|Target/Specificity||This CXCR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CXCR5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CXCR5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expression in mature B-cells and Burkitt lymphoma cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene was identified as a gene specifically expressed in Burkitt's lymphoma and lymphatic tissues. The protein encoded by this gene is predicted to be a seven transmembrane G protein- coupled receptor and belongs to the CXC chemokine receptor family. BLC, a B-lymphocyte chemoattractant, was identified to be a specific ligand for this receptor. Studies of this gene and its mouse conterpart strongly suggest the essential function of this gene in B cell migration and localization within specific anatomic compartments, such as follicles in lymph nodes as well as in spleen. Two alternatively spliced variants of this gene exist.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Lee, H.T., et al. J. Rheumatol. 37(1):45-52(2010)
El Haibi, C.P., et al. Mol. Cancer 9, 85 (2010) :
Singh, S., et al. Int. J. Cancer 125(10):2288-2295(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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