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BLOC1S3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BLOC1S3 Antibody (C-term) AP19902B
    BLOC1S3 Antibody (C-term) (Cat. #AP19902b) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the BLOC1S3 antibody detected the BLOC1S3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6QNY0
Other Accession NP_997715.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 21256 Da
Antigen Region 176-202 aa
Additional Information
Gene ID 388552
Other Names Biogenesis of lysosome-related organelles complex 1 subunit 3, BLOC-1 subunit 3, BLOC1S3, BLOS3
Target/Specificity This BLOC1S3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 176-202 amino acids from the C-terminal region of human BLOC1S3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBLOC1S3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BLOC1S3
Synonyms BLOS3
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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This gene encodes a protein that is a component of the BLOC1 multi-subunit protein complex. This complex is necessary for the biogenesis of specialized organelles of the endosomal-lysosomal system, including platelet dense granules and melanosomes. Mutations in this gene cause Hermansky-Pudlak syndrome 8, a disease characterized by lysosomal storage defects, bleeding due to platelet storage pool deficiency, and oculocutaneous albinism.


Seshadri, S., et al. JAMA 303(18):1832-1840(2010)
Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Morgan, N.V., et al. Am. J. Hum. Genet. 78(1):160-166(2006)
Starcevic, M., et al. J. Biol. Chem. 279(27):28393-28401(2004)

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$ 295.00
$ 99.00
Cat# AP19902B
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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