NR2E1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9Y466 |
Other Accession | P70052, Q64104, Q91379, NP_003260.1 |
Reactivity | Human |
Predicted | Chicken, Mouse, Xenopus |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42589 Da |
Antigen Region | 75-102 aa |
Gene ID | 7101 |
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Other Names | Nuclear receptor subfamily 2 group E member 1, Nuclear receptor TLX, Protein tailless homolog, Tll, hTll, NR2E1, TLX |
Target/Specificity | This NR2E1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-102 amino acids from the Central region of human NR2E1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | NR2E1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | NR2E1 |
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Synonyms | TLX |
Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells. |
Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. |
Tissue Location | Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required for brain development. May be involved in the regulation of retinal development (By similarity).
References
Liu, H.K., et al. Genes Dev. 24(7):683-695(2010)
Iwahara, N., et al. Biochem. Biophys. Res. Commun. 386(4):671-675(2009)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Kumar, R.A., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (6), 880-889 (2008) :
Yokoyama, A., et al. Mol. Cell. Biol. 28(12):3995-4003(2008)
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