|Application ||WB, E|
|Calculated MW||86975 Da|
|Antigen Region||685-713 aa|
|Other Names||Relaxin receptor 1, Leucine-rich repeat-containing G-protein coupled receptor 7, Relaxin family peptide receptor 1, RXFP1, LGR7|
|Target/Specificity||This RXFP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 685-713 amino acids from the C-terminal region of human RXFP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RXFP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Halls, M.L., et al. EMBO J. 29(16):2772-2787(2010)
Singh, S., et al. Mol. Cell. Endocrinol. 315 (1-2), 239-245 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Feng, S., et al. Ann. N. Y. Acad. Sci. 1160, 379-380 (2009) :
Li, Z., et al. Ann. N. Y. Acad. Sci. 1160, 374-378 (2009) :
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