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RXFP1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RXFP1 Antibody (C-term) AP19927B
    RXFP1 Antibody (C-term) (Cat. #AP19927b) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the RXFP1 antibody detected the RXFP1 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9HBX9
Other Accession NP_067647.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 86975 Da
Antigen Region 685-713 aa
Additional Information
Gene ID 59350
Other Names Relaxin receptor 1, Leucine-rich repeat-containing G-protein coupled receptor 7, Relaxin family peptide receptor 1, RXFP1, LGR7
Target/Specificity This RXFP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 685-713 amino acids from the C-terminal region of human RXFP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRXFP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RXFP1
Synonyms LGR7
Function Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen.
Research Areas
Citations (0)

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Background

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.

References

Halls, M.L., et al. EMBO J. 29(16):2772-2787(2010)
Singh, S., et al. Mol. Cell. Endocrinol. 315 (1-2), 239-245 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Feng, S., et al. Ann. N. Y. Acad. Sci. 1160, 379-380 (2009) :
Li, Z., et al. Ann. N. Y. Acad. Sci. 1160, 374-378 (2009) :

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Cat# AP19927B
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(40 western blots)
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