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CASQ2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CASQ2 Antibody (Center) AP19929c
    CASQ2 Antibody (Center) (Cat. #AP19929c) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the CASQ2 antibody detected the CASQ2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14958
Other Accession P31235, NP_001223.2
Reactivity Human
Predicted Rabbit
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46436 Da
Antigen Region 79-107 aa
Additional Information
Gene ID 845
Other Names Calsequestrin-2, Calsequestrin, cardiac muscle isoform, CASQ2
Target/Specificity This CASQ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the Central region of human CASQ2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCASQ2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CASQ2
Function Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Cellular Location Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:O09161}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells {ECO:0000250|UniProtKB:O09161}
Research Areas
Citations (0)

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The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq].


Kirchhefer, U., et al. J. Mol. Cell. Cardiol. 49(1):95-105(2010)
Wong, C.H., et al. Forensic Sci. Int. 192 (1-3), 53-55 (2009) :
Liu, J., et al. Am. J. Physiol., Cell Physiol. 297 (1), C152-C159 (2009) :
Hayashi, M., et al. Circulation 119(18):2426-2434(2009)
Wei, L., et al. Cell Calcium 45(5):474-484(2009)

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$ 295.00
$ 99.00
Cat# AP19929c
(40 western blots)
Availability: In Stock
Bulk Size
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