|Application ||WB, E|
|Calculated MW||42404 Da|
|Antigen Region||122-150 aa|
|Other Names||Serpin B9, Cytoplasmic antiproteinase 3, CAP-3, CAP3, Peptidase inhibitor 9, PI-9, SERPINB9, PI9|
|Target/Specificity||This SERPINB9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-150 amino acids from the Central region of human SERPINB9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SERPINB9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Granzyme B inhibitor.|
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Provided below are standard protocols that you may find useful for product applications.
PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995 [PubMed 8530382]).
Rousalova, I., et al. Int. J. Oncol. 36(1):275-283(2010)
Jiang, X., et al. Endocrinology 149(11):5366-5373(2008)
Bots, M., et al. Hum. Immunol. 68(12):959-964(2007)
Kummer, J.A., et al. Cell Death Differ. 14(8):1486-1496(2007)
Jiang, X., et al. Oncogene 26(28):4106-4114(2007)
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