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NLN Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NLN Antibody (Center) AP19932c
    NLN Antibody (Center) (Cat. #AP19932c) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the NLN antibody detected the NLN protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9BYT8
Other Accession NP_065777.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 80652 Da
Antigen Region 212-240 aa
Additional Information
Gene ID 57486
Other Names Neurolysin, mitochondrial, Angiotensin-binding protein, Microsomal endopeptidase, MEP, Mitochondrial oligopeptidase M, Neurotensin endopeptidase, NLN, AGTBP, KIAA1226
Target/Specificity This NLN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of human NLN.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNLN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NLN
Synonyms AGTBP, KIAA1226
Function Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity). Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
Cellular Location Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P42676}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P42676}
Research Areas
Citations (0)
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Background

This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Lim, E.J., et al. J. Biol. Chem. 282(13):9722-9732(2007)
Norman, M.U., et al. Am. J. Physiol. Heart Circ. Physiol. 284 (6), H1978-H1984 (2003) :
Norman, M.U., et al. Am. J. Physiol. Heart Circ. Physiol. 284 (6), H1978-H1984 (2003) :
Garrido, P.A., et al. DNA Cell Biol. 18(4):323-331(1999)

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$ 182.50
$ 70.00
Cat# AP19932c
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