|Application ||WB, E|
|Calculated MW||22511 Da|
|Antigen Region||168-197 aa|
|Other Names||Ras-related protein Rab-7b, RAB7B|
|Target/Specificity||This RAB7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human RAB7B.|
|Precautions||RAB7B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.|
|Cellular Location||Late endosome. Lysosome. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis|
|Tissue Location||Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte|
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Provided below are standard protocols that you may find useful for product applications.
Protein transport. Probably involved in vesicular traffic (By similarity).
Progida, C., et al. J. Cell. Sci. 123 (PT 9), 1480-1491 (2010) :
Yang, M., et al. Biochem. Biophys. Res. Commun. 318(3):792-799(2004)
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