|Application ||WB, E|
|Calculated MW||39008 Da|
|Antigen Region||205-234 aa|
|Other Names||Renin receptor, ATPase H(+)-transporting lysosomal accessory protein 2, ATPase H(+)-transporting lysosomal-interacting protein 2, ER-localized type I transmembrane adaptor, Embryonic liver differentiation factor 10, N14F, Renin/prorenin receptor, Vacuolar ATP synthase membrane sector-associated protein M8-9, ATP6M8-9, V-ATPase M89 subunit, ATP6AP2, ATP6IP2, CAPER, ELDF10|
|Target/Specificity||This ATP6AP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human ATP6AP2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATP6AP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ATP6IP2, CAPER, ELDF10|
|Function||Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases.
Takahashi, K., et al. Peptides 31(7):1405-1408(2010)
Cruciat, C.M., et al. Science 327(5964):459-463(2010)
Nabi, A.H., et al. Biochim. Biophys. Acta 1794(12):1838-1847(2009)
Alcazar, O., et al. Exp. Eye Res. 89(5):638-647(2009)
Takemitsu, T., et al. Am. J. Nephrol. 30(4):361-370(2009)
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