|Application ||WB, E|
|Calculated MW||80856 Da|
|Antigen Region||694-720 aa|
|Other Names||Fc receptor-like protein 3, FcR-like protein 3, FcRL3, Fc receptor homolog 3, FcRH3, IFGP family protein 3, hIFGP3, Immune receptor translocation-associated protein 3, SH2 domain-containing phosphatase anchor protein 2, CD307c, FCRL3, FCRH3, IFGP3, IRTA3, SPAP2|
|Target/Specificity||This FCRL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 694-720 amino acids from the C-terminal region of human FCRL3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FCRL3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FCRH3, IFGP3, IRTA3, SPAP2|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B-cells but also expressed in NK cells (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.
Wu, H., et al. Hum. Immunol. (2010) In press :
Swainson, L.A., et al. J. Immunol. 184(7):3639-3647(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Zheng, R., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26(6):681-685(2009)
Gibson, A.W., et al. Arthritis Rheum. 60(11):3510-3512(2009)
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