|Application ||WB, E|
|Calculated MW||33394 Da|
|Antigen Region||167-194 aa|
|Other Names||Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, HAVCR2, TIM3, TIMD3|
|Target/Specificity||This HAVCR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-194 amino acids from the Central region of human HAVCR2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HAVCR2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||T-helper type 1 lymphocyte (Th1)-specific.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Cao, B., et al. Cancer Immunol. Immunother. 59(12):1851-1857(2010)
Dorfman, D.M., et al. Hum. Pathol. 41(10):1486-1494(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Dardalhon, V., et al. J. Immunol. 185(3):1383-1392(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
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