|Application ||WB, E|
|Calculated MW||45303 Da|
|Antigen Region||314-342 aa|
|Other Names||Poliovirus receptor, Nectin-like protein 5, NECL-5, CD155, PVR, PVS|
|Target/Specificity||This PVR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-342 amino acids from the C-terminal region of human PVR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PVR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.|
|Cellular Location||Isoform Alpha: Cell membrane; Single-pass type I membrane protein Isoform Beta: Secreted.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.
Nakai, R., et al. Cancer Sci. 101(5):1326-1330(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Stanietsky, N., et al. Proc. Natl. Acad. Sci. U.S.A. 106(42):17858-17863(2009)
Carlsten, M., et al. J. Immunol. 183(8):4921-4930(2009)
Kindberg, E., et al. J. Med. Virol. 81(5):933-936(2009)
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