|Application ||WB, E|
|Calculated MW||70971 Da|
|Antigen Region||40-67 aa|
|Other Names||Zinc finger protein 93, Zinc finger protein 505, Zinc finger protein HTF34, ZNF93, ZNF505|
|Target/Specificity||This ZNF93 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-67 amino acids from the N-terminal region of human ZNF93.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNF93 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). Not able to repress expression of all subtypes of L1 elements. Binds to the 5' end of L1PA4, L1PA5 and L1PA6 subtypes, and some L1PA3 subtypes. Does not bind to L1PA7 or older subtypes nor at the most recently evolved L1PA2 and L1Hs. 50% of L1PA3 elements have lost the ZNF93-binding site, explaining why ZNF93 is not able to repress their expression (PubMed:25274305).|
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Provided below are standard protocols that you may find useful for product applications.
May be involved in transcriptional regulation.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Duan, Z., et al. PLoS ONE 4 (9), E6967 (2009) :
Caporaso, N., et al. PLoS ONE 4 (2), E4653 (2009) :
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Bellefroid, E.J., et al. EMBO J. 12(4):1363-1374(1993)
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