|Application ||WB, E|
|Calculated MW||142737 Da|
|Antigen Region||667-695 aa|
|Other Names||Tau-tubulin kinase 1, Brain-derived tau kinase, TTBK1, BDTK, KIAA1855|
|Target/Specificity||This TTBK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 667-695 amino acids from the Central region of human TTBK1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TTBK1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.|
|Tissue Location||Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea.|
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Provided below are standard protocols that you may find useful for product applications.
Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.
Vazquez-Higuera, J.L., et al. Neurobiol. Aging (2010) In press :
Sato, S., et al. J. Neurosci. 28(53):14511-14521(2008)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Takahashi, M., et al. FEBS Lett. 372(1):59-64(1995)
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