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PDE8B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95263 |
| Other Accession | E9Q4S1, NP_003710.1 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 98979 Da |
| Antigen Region | 296-324 aa |
| Gene ID | 8622 |
|---|---|
| Other Names | High affinity cAMP-specific and IBMX-insensitive 3', 5'-cyclic phosphodiesterase 8B, HsPDE8B, Cell proliferation-inducing gene 22 protein, PDE8B |
| Target/Specificity | This PDE8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-324 amino acids from the Central region of human PDE8B. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PDE8B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PDE8B |
|---|---|
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. |
| Tissue Location | Abundantly expressed in the thyroid. Also very weakly expressed in brain, spinal cord and placenta. In the thyroid isoform 1 predominates, and isoforms 2 and 6 are also highly expressed In the placenta isoforms 1 and 2 are expressed equally. In the brain isoform 2 predominates. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.
References
Horvath, A., et al. Thyroid 20(4):363-367(2010)
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Appenzeller, S., et al. Am. J. Hum. Genet. 86(1):83-87(2010)
Shields, B.M., et al. J. Clin. Endocrinol. Metab. 94(11):4608-4612(2009)
Bimpaki, E.I., et al. Eur. J. Endocrinol. 161(1):153-161(2009)
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