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HPS5 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HPS5 Antibody (N-term) AP20048a
    HPS5 Antibody (N-term) (Cat. #AP20048a) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the HPS5 antibody detected the HPS5 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UPZ3
Other Accession NP_009147.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 127449 Da
Antigen Region 88-116 aa
Additional Information
Gene ID 11234
Other Names Hermansky-Pudlak syndrome 5 protein, Alpha-integrin-binding protein 63, Ruby-eye protein 2 homolog, Ru2, HPS5, AIBP63, KIAA1017
Target/Specificity This HPS5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the N-terminal region of human HPS5.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHPS5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HPS5
Synonyms AIBP63, KIAA1017
Function May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins.
Cellular Location Cytoplasm, cytosol.
Tissue Location Widely expressed. Isoform 1:Highly expressed in lungs and testis. Isoform 2:Highly expressed in placenta, kidney, testis ovary, lung and thymus.
Research Areas
Citations (0)
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Background

This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. This protein interacts with Hermansky-Pudlak syndrome 6 protein and may interact with the cytoplasmic domain of integrin, alpha-3. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 5. Multiple transcript variants encoding two distinct isoforms have been identified for this gene.

References

Helip-Wooley, A., et al. J. Invest. Dermatol. 127(6):1471-1478(2007)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Huizing, M., et al. Platelets 18(2):150-157(2007)
Huizing, M., et al. Traffic 5(9):711-722(2004)
Di Pietro, S.M., et al. Traffic 5(4):276-283(2004)

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$ 365.00
$ 140.00
Cat# AP20048a
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