|Application ||WB, E|
|Calculated MW||37607 Da|
|Antigen Region||136-164 aa|
|Other Names||Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH-L5, Ubiquitin C-terminal hydrolase UCH37, Ubiquitin thioesterase L5, UCHL5, UCH37|
|Target/Specificity||This UCHL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-164 amino acids from the Central region of human UCHL5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UCHL5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.|
|Cellular Location||Cytoplasm. Nucleus. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome.
Nishio, K., et al. Biochem. Biophys. Res. Commun. 390(3):855-860(2009)
Yao, T., et al. Mol. Cell 31(6):909-917(2008)
Koulich, E., et al. Mol. Biol. Cell 19(3):1072-1082(2008)
Qiu, X.B., et al. EMBO J. 25(24):5742-5753(2006)
Hamazaki, J., et al. EMBO J. 25(19):4524-4536(2006)
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