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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   BMPR1B Antibody (C-term)   

BMPR1B Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BMPR1B Antibody (C-term) AP2005B
    Western blot analysis of anti-BMPR1B Pab (Cat. #ap2005b) in NCI-H460 cell lysate. BMPR1B (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
  • IHC-P - BMPR1B Antibody (C-term) AP2005B
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00238
Other Accession P36898, Q05438, NP_001194
Reactivity Human
Predicted Mouse, Chicken
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 56930 Da
Antigen Region 472-502 aa
Additional Information
Gene ID 658
Other Names Bone morphogenetic protein receptor type-1B, BMP type-1B receptor, BMPR-1B, CDw293, BMPR1B
Target/Specificity This BMPR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-502 amino acids from the C-terminal region of human BMPR1B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBMPR1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Research Areas
Citations ( 0 )


The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.


Kan, L. et al. Stem Cells.January; 27(1): 150?56( 2009).
Lehmann, K., et al., Proc. Natl. Acad. Sci. U.S.A. 100(21):12277-12282 (2003).
Astrom, A.K., et al., Mamm. Genome 10(3):299-302 (1999).
Ide, H., et al., Oncogene 14(11):1377-1382 (1997).
ten Dijke, P., et al., Science 264(5155):101-104 (1994).
Ide, H., et al., Cytogenet. Cell Genet. 81 (3-4), 285-286 (1998).

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$ 295.00
$ 99.00
Cat# AP2005B
(40 western blots)
Availability: In Stock
Bulk Size
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