|Application ||WB, E|
|Other Accession||P07742, NP_001024.1|
|Calculated MW||90070 Da|
|Antigen Region||71-100 aa|
|Other Names||Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RRM1, RR1|
|Target/Specificity||This RRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human RRM1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RRM1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Vinolas, N., et al. Lung Cancer (2010) In press :
Niida, H., et al. Genes Dev. 24(4):333-338(2010)
Dong, S., et al. J Hematol Oncol 3, 10 (2010) :
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