|Application ||IF, WB, E|
|Other Accession||P31257, NP_059105.2|
|Calculated MW||38073 Da|
|Antigen Region||224-250 aa|
|Other Names||Homeobox protein Hox-C10, Homeobox protein Hox-3I, HOXC10, HOX3I|
|Target/Specificity||This HOXC10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-250 amino acids from the C-terminal region of human HOXC10.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HOXC10 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.
Hwang, J.H., et al. Cloning Stem Cells 11(2):269-279(2009)
Zhai, Y., et al. Cancer Res. 67(21):10163-10172(2007)
Gabellini, D., et al. EMBO J. 22(14):3715-3724(2003)
Kosaki, K., et al. Teratology 65(2):50-62(2002)
Sandrock, B., et al. J. Biol. Chem. 276(38):35328-35333(2001)
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