|Application ||WB, E|
|Other Accession||O73612, NP_004420.1|
|Calculated MW||38007 Da|
|Antigen Region||88-116 aa|
|Other Names||Ephrin-B1, EFL-3, ELK ligand, ELK-L, EPH-related receptor tyrosine kinase ligand 2, LERK-2, EFNB1, EFL3, EPLG2, LERK2|
|Target/Specificity||This EFNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the Central region of human EFNB1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EFNB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||EFL3, EPLG2, LERK2|
|Function||Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system.
Hogue, J., et al. Am. J. Med. Genet. A 152A (10), 2574-2577 (2010) :
Arvanitis, D.N., et al. Mol. Cell. Biol. 30(10):2508-2517(2010)
Makarov, R., et al. BMC Med. Genet. 11, 98 (2010) :
Vazin, T., et al. PLoS ONE 4 (8), E6606 (2009) :
Wallis, D., et al. Am. J. Med. Genet. A 146A (15), 2008-2012 (2008) :
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