|Application ||WB, IHC-P, E|
|Other Accession||A1XD95, NP_036275.1|
|Calculated MW||96820 Da|
|Antigen Region||42-70 aa|
|Other Names||Tuftelin-interacting protein 11, Septin and tuftelin-interacting protein 1, STIP-1, TFIP11, STIP|
|Target/Specificity||This TFIP11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 amino acids from the N-terminal region of human TFIP11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TFIP11 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.|
|Cellular Location||Cytoplasm. Nucleus. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles.|
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Provided below are standard protocols that you may find useful for product applications.
TFIP11 is a nuclear speckle-localized protein that may play a role in spliceosome disassembly in Cajal bodies (Stanek et al., 2008 [PubMed 18367544]).
Saus, E., et al. J Psychiatr Res (2010) In press :
Tannukit, S., et al. Biochem. Biophys. Res. Commun. 390(3):1044-1050(2009)
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
Stanek, D., et al. Mol. Biol. Cell 19(6):2534-2543(2008)
Patir, A., et al. Caries Res. 42(5):394-400(2008)
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