|Application ||WB, E|
|Calculated MW||31728 Da|
|Antigen Region||239-267 aa|
|Other Names||Methylmalonic aciduria and homocystinuria type C protein, MMACHC|
|Target/Specificity||This MMACHC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-267 amino acids from the C-terminal region of human MMACHC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MMACHC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the binding and intracellular trafficking of cobalamin (vitamin B12).|
|Tissue Location||Widely expressed. Expressed at higher level in fetal liver. Also expressed in spleen, lymph node, thymus and bone marrow. Weakly or not expressed in peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
The exact function of the protein encoded by this gene is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this gene are associated with methylmalonic aciduria and homocystinuria type cblC.
Froese, D.S., et al. Mol. Genet. Metab. 100(1):29-36(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Profitlich, L.E., et al. Mol. Genet. Metab. 98(4):344-348(2009)
Kim, J., et al. J. Biol. Chem. 284(48):33418-33424(2009)
Richard, E., et al. Hum. Mutat. 30(11):1558-1566(2009)
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