|Application ||WB, IF, IHC-P, E|
|Other Accession||Q8BG81, NP_115687.2|
|Calculated MW||46089 Da|
|Antigen Region||93-120 aa|
|Other Names||Polymerase delta-interacting protein 3, 46 kDa DNA polymerase delta interaction protein, p46, S6K1 Aly/REF-like target, SKAR, POLDIP3, KIAA1649, PDIP46|
|Target/Specificity||This POLDIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-120 amino acids from the N-terminal region of human POLDIP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POLDIP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.|
|Cellular Location||Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified. [provided by RefSeq].
Ma, X.M., et al. Cell 133(2):303-313(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Smyk, A., et al. FEBS J. 273(20):4728-4741(2006)
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
Richardson, C.J., et al. Curr. Biol. 14(17):1540-1549(2004)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.