|Application ||WB, IF, IHC-P, E|
|Other Accession||Q8BG81, NP_115687.2|
|Calculated MW||46089 Da|
|Antigen Region||93-120 aa|
|Other Names||Polymerase delta-interacting protein 3, 46 kDa DNA polymerase delta interaction protein, p46, S6K1 Aly/REF-like target, SKAR, POLDIP3, KIAA1649, PDIP46|
|Target/Specificity||This POLDIP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 93-120 amino acids from the N-terminal region of human POLDIP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POLDIP3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex.|
|Cellular Location||Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified. [provided by RefSeq].
Ma, X.M., et al. Cell 133(2):303-313(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Smyk, A., et al. FEBS J. 273(20):4728-4741(2006)
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
Richardson, C.J., et al. Curr. Biol. 14(17):1540-1549(2004)
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