|Application ||WB, E|
|Calculated MW||16232 Da|
|Antigen Region||117-145 aa|
|Other Names||Selenoprotein M, SelM, SELM, SEPM|
|Target/Specificity||This SELM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-145 amino acids from the C-terminal region of human SELM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SELM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.|
|Cellular Location||Cytoplasm, perinuclear region. Endoplasmic reticulum. Golgi apparatus. Note=Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This gene is expressed in a variety of tissues, and the protein is localized to the perinuclear structures. [provided by RefSeq].
Korotkov, K.V., et al. Mol. Cell. Biol. 22(5):1402-1411(2002)
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