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FUNDC2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9BWH2 |
| Other Accession | Q864V5, Q9D6K8, Q8MJN0, NP_076423.2 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20676 Da |
| Antigen Region | 122-150 aa |
| Gene ID | 65991 |
|---|---|
| Other Names | FUN14 domain-containing protein 2, Cervical cancer proto-oncogene 3 protein, HCC-3, Hepatitis C virus core-binding protein 6, FUNDC2, HCBP6 |
| Target/Specificity | This FUNDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-150 amino acids from the C-terminal region of human FUNDC2. |
| Dilution | WB~~1:500-1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FUNDC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FUNDC2 (HGNC:24925) |
|---|---|
| Synonyms | HCBP6 |
| Function | Binds directly and specifically 1,2-Diacyl-sn-glycero-3- phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (PubMed:29187281, PubMed:25855506). |
| Cellular Location | Mitochondrion outer membrane; Multi-pass membrane protein. Nucleus |
| Tissue Location | Highly expressed in platelets (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein is unknown.
References
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Li, K., et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 16(4):351-353(2002)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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