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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   LYVE1 (XLKD1) Antibody (C-term)   

LYVE1 (XLKD1) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • IHC-P - LYVE1 (XLKD1) Antibody (C-term) AP2015b
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
  • WB - LYVE1 (XLKD1) Antibody (C-term) AP2015b
    XLKD1 Antibody (C-term) (Cat. #AP2015b) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the XLKD1 antibody detected the XLKD1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y5Y7
Other Accession Q6UC88, NP_006682
Reactivity Human
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 35213 Da
Antigen Region 243-272 aa
Additional Information
Gene ID 10894
Other Names Lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE-1, Cell surface retention sequence-binding protein 1, CRSBP-1, Extracellular link domain-containing protein 1, Hyaluronic acid receptor, LYVE1, CRSBP1, HAR, XLKD1
Target/Specificity This LYVE1 (XLKD1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the C-terminal region of human LYVE1 (XLKD1).
Dilution IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLYVE1 (XLKD1) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LYVE1
Synonyms CRSBP1, HAR, XLKD1
Function Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
Cellular Location Membrane; Single-pass type I membrane protein Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand- dependent internalization and recycling at the cell surface
Tissue Location Mainly expressed in endothelial cells lining lymphatic vessels.
Research Areas
Citations (0)

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XLKD1 is a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis.


Jackson, D.G., Trends Cardiovasc. Med. 13(1):1-7 (2003). Cursiefen, C., et al., Invest. Ophthalmol. Vis. Sci. 43(7):2127-2135 (2002). Cunnick, G.H., et al., Biochem. Biophys. Res. Commun. 288(4):1043-1046 (2001). Mouta Carreira, C., et al., Cancer Res. 61(22):8079-8084 (2001). Banerji, S., et al., J. Cell Biol. 144(4):789-801 (1999).

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$ 295.00
$ 99.00
Cat# AP2015b
(40 western blots)
Availability: In Stock
Bulk Size
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